Q: What is MIA?
A: MIA is firstly open source website to publish mappings between ICD 10 codes to ATC codes. Based on the ATC fifth level codes of drugs and the ICD codes, Totally, there are 3420 mapping entries. It could help the utilization or reutilization of drugs and the drug pricing and reimbursement policies.
Q: Functions provided in MIA?
A: 1. Lists Browsing:
(i) ATC-ICD List, map ICD disease codes with ATC drug codes throught the DrugBank drugs. Up to date 1194 ATC codes are mapped to 980 ICD codes manually generating 3420 ICD-ATC mappings.
(ii) Drug ATC List, obtain from an official ATC documentation at http://ec.europa.eu/health/documents/community-register/html/atc.htm.
(iii) Disease ICD 10 List, obtain from ICD 10 official application - International Statistical Classification of Diseases and Related Health Problems 10th Revision at http://apps.who.int/classifications/icd10/browse/2010/en.
2. Search Functions:
Choose the different tabs to select the desired kind of input. Searching types are availables of Structure, Fragment, Drug Name, Disease Name, ATC and ICD IDs.
Q: How to use MIA(search functions)?
A: 1. Users can inquire ICD / ATC codes in corresponding tabs to get the results, which contain the input ATC / ICD code, the mapping ATC / ICD codes, the bridge drug, and which level(s) them mapping. When input keyword is not a level 5 ATC code( or level 4 ICD code), it will inquire all subcodes of the keyword in MIA.
2. Users can retrieval the bridge drug to get the results by searching drug names or drug molecular SMILES (Structure tab). MIA allows researchers to input a compound in SMILES format or to draw one online. Fragment tab is searching bridge drugs contain the input fragment.
3. Users also can search disease name to get the disease's ICD codes, treatment durgs, and the drugs' atc codes.
Q: Searching cases available in MIA?
A:For example, Search O=C1C(N)C2SCC=C(C(=O)O)N12 in Fragment, MIA gives 41 ATC-ICD mappings (partly show in Fig. 1C) and 26 related drugs (partly show in Fig. 1D). For each mapping record, related ICD codes, ATC codes, bridge drugs have been linked to original websites.